Dr. Silvia Fossati is an Associate Professor of Pharmacology and Associate Director of the Alzheimer’s Center at Temple University at the Lewis Katz School of Medicine. She has been awarded a two-year $500,000 grant from The Edward N. and Della L. Thome Memorial Foundation, Bank of America, N.A., Trustee, as part of the Foundation’s Awards Program in Alzheimer’s disease Drug Discovery Research.
Dr. Fossati, along with her colleague Marc Ilies, Ph.D. and Professor of the Department of Pharmaceutical Sciences, is investigating to create a new Alzheimer Specific Drug out of an existing drug family. They are called carbonic anhydrase inhibitors, which are accepted by the US Food and Drug Administration to cure Glaucoma and High altitude Sickness. The drug is successful in the cell and animal model for some Alzheimer’s traits. They are mitochondrial dysfunction, amyloid protein build-up, and inflammation, as suggested by Lab Studies.
Furthermore, the findings elaborate that chronic inflammation is caused by building up cells in the brain that usually free the organ from debris, waste, and protein collections- also amyloid protein. The abnormal deposition of amyloid protein in the brain causes the interruption in cell function and communication pathways. Abnormalities of the mitochondria, the energy-generating batteries of cells, and in damaging the brain vasculature (its blood vessels) constitute the factors of elevated levels. And, the result is thinking disability, impairments in memory, and learning. The key focus areas of Dr. Fossati and Dr. Ilies’s research, which infiltrate the brain with fewer side effects and with much efficiency. The tests are first carried out in cell and animal models, after which they will be tried on humans.
Dr. Fossati quoted saying they are thankful to the foundation for genuinely recognizing their effort and granted this research. And they will modify the options available in the market.
The foundation that has granted the money for this research is known as The Edward N. and Della L. Thome Memorial Foundation, Bank of America, N.A., Trustee, established in 2002 by Robert P.Thome to honor the memory of his parents. The funds are for two specified areas – Treatment to older adults and medical research on older adults. Temple University Health System is a $2.2 billion academic health system dedicated to providing quality health care of patients and also supports medical education and research.