Oregon Health & Science University (OHSU) has come up with another breakthrough invention as its scientists have developed a compound that encourages the repair of the nerve cell-protective myelin sheath that is damaged in diseases such as multiple sclerosis (MS). an international research team that is led by the OHSU researchers reports on positive results wit the modified flavonoid compound, S#, in culture and in live mice. They post their findings in a paper published in Gila. They are currently evaluating S3 in a rare population of macaque monkeys located at the Oregon National Primate Research Center at OHSU, which instinctively develops a disease that is similar to MS in humans.
Larry Sherman, Ph.D., an OHSU professor in the division of neuroscience at the primate center shared that they will be able to evaluate in a year whether the drug can be used in human clinical trials or not. However, if it does not work, they will know from the mouse studies that this approach is correct, and the major question will be whether it can be adapted to bigger human brains. ‘
nerve cell axons are surrounded by a myelin sheath which is vital for normal nerve cell function and the transmission of electrical signals.
damage to myelin is usually caused by diseases like MS, this may also happen in case of a stroke, brain injuries, and in some types of dementia such as Alzheimer’s disease. Some studies have proposed that an interruption or delay in nerve cell myelination due to the failure of OPCs to mature into myelin-forming OLs could be responsible for poor myelination in both the adult brain and in infants born prematurely, leading to brain damage. Further research has concluded that the ability to activate OPC maturation could represent a therapeutic strategy for promoting remyelination.