Transplanting an organ by synthethic means using micro particle

Research by the University of Pittsburgh says tiny particles of cell size can trick the body by accepting transplanted tissue as its own. The experiment done on rats showed strange results. Tissues of cell size microparticles developed a permanent immune to surgical procedure. A whole limb was transplanted from a donor rat to a receiver while keeping the system intact. This is a study published in Science Advances.

Dr. Steven Little said that this procedure is just like hacking into the immune system and tricking the body to accept a transplant by synthetic means.

In contrast to cell-based therapies, he said, the benefits of synthetic treatment are it is simpler in logistical means. Author James, M.D, Ph.D., enlightens the way in the way they perform the procedure by growing the cell in a laboratory than isolating them from a patient. A native protein secreted by tumors, CCL22 has released that draw Treg cells to the site of surgery where they tag a transplanted tissue as their evading immune attack.

It is published in other papers as well that the immune system of one rat accepts donor limb from another strain. However, the grafts from the third strain get rejected rapidly. Presently, there are drugs available to avoid rejections, but these drugs trigger the immune system making them weak and open to attack from the transplanted organ which does not protect the body either.

Angus Thomson, Ph.D., stated that the ability to tolerate the transplant while ignoring systemic immunosuppression is important in the context of vascularized composite transplantation where patients receive quality-of-life transplants, such as those of hands or face.

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